In order to enhance the objectivity, accuracy and convenience of power quality comprehensive evaluation of distributed power supply, a new power quality comprehensive evaluation method is proposed with the increasing of large-scale new energy grid-connected and users’ demand for power quality. Firstly, the index system of power quality comprehensive evaluation is established. Secondly, in view of the one-sidedness of a single subjective and objective weighting, The subjective weight is determined by the relational analysis method, the objective weight is determined by the improved entropy method, and finally the game theory introduced into the Specific mode combination of the subjective and the objective weights to obtain the optimal combined weights of each index. Then the QUALIFLEX algorithm model is used to evaluate the power quality comprehensively. The traditional evaluation models such as radar map and cloud model are compared for reference. Finally, the power quality evaluation results obtained by this method are consistent with the actual situation, which proves the accuracy and feasibility of the proposed algorithm.