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Post-stroke movement disorder (PSMD) is one of the most common complications after stroke in need of effective methods of rehabilitation. Repetitive transcranial magnetic stimulation (rTMS) could regulate brain excitability and improve motor function of stroke patients by inducing intracranial electric currents in the brain through a fluctuating magnetic field. However, the improvement effect of rTMS intervention is quite variable. The regulation mechanism of rTMS combined movement intention (TCMI) related brain activity is still not clear. 16 stroke participant with PSMD were recruited and rTMS was applied to the primary motor cortex (M1) combined with movement intention. Changes of behavior and brain activity were compared and analyzed before and after the 5-days intervention. Results: The composite recovery scores of stroke patients were significantly higher after intervention than before (P < 0.05). Brain activities were enhanced significantly for the positive response participants (P < 0.05). Conclusions: TCMI intervention contributes to improvements in motor function of stroke patients, and the characterization of brain activity before and after intervention may be a biomarker of degree of rehabilitation, which could be used for clinical screening stroke patients who are suitable for rTMS.

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Regulatory Effect of Transcranial Magnetic Stimulation Combined Movement Intention on Improving Motor Function After Stroke

  • 会议论文

  • 发表日期：

    2025年

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  • Jing Yang,
  • Lingdi Fu,
  • Liyong Yin,
  • Shixing Li,
  • Jiawei Feng,
  • Guizhi Xu,
  • Zhenhu Liang

摘要

Post-stroke movement disorder (PSMD) is one of the most common complications after stroke in need of effective methods of rehabilitation. Repetitive transcranial magnetic stimulation (rTMS) could regulate brain excitability and improve motor function of stroke patients by inducing intracranial electric currents in the brain through a fluctuating magnetic field. However, the improvement effect of rTMS intervention is quite variable. The regulation mechanism of rTMS combined movement intention (TCMI) related brain activity is still not clear. 16 stroke participant with PSMD were recruited and rTMS was applied to the primary motor cortex (M1) combined with movement intention. Changes of behavior and brain activity were compared and analyzed before and after the 5-days intervention. Results: The composite recovery scores of stroke patients were significantly higher after intervention than before (P < 0.05). Brain activities were enhanced significantly for the positive response participants (P < 0.05). Conclusions: TCMI intervention contributes to improvements in motor function of stroke patients, and the characterization of brain activity before and after intervention may be a biomarker of degree of rehabilitation, which could be used for clinical screening stroke patients who are suitable for rTMS.