The engagement of entrepreneurial organizations in foreign trade plays a crucial role in the global economy, enhancing economic integration and stability among nations. The primary objective of this research is to scrutinize the determinants influencing these operations and their repercussions on economic advancement, evolution, and affluence. Employing an econometric methodology, specifically the autoregressive distributed lag (ARDL) model, was imperative to evaluate the influence of various macroeconomic parameters on the foreign trade endeavors of entrepreneurial entities. Empirical data spanning from 2016 to 2023 was amassed from diverse sources such as the State Committee on Statistics, the Central Bank, and the Customs Committee of Uzbekistan. The outcomes divulge that customs value, import volume, total benefits, and exchange rate wield a substantial impact on customs duties. Notably, a mere 1% escalation in customs value, import volume, and exchange rate yields a proportional rise in customs duties by 0.88%, 0.45%, and 0.93%, respectively. Conversely, a 1% upsurge in total benefits triggers a decline in customs duties by 0.42%. These findings underscore the intricate interplay between macroeconomic indicators and the performance of foreign trade. The positive relationship between customs value, import volume, exchange rate, and customs duties underscores the significance of these factors in shaping trade strategies. This analysis furnishes crucial insights into the determinants of the foreign trade operations of entrepreneurial entities. Policymakers can leverage these insights to enhance trade frameworks, fostering economic growth and stability. Subsequent research endeavors could enrich these discoveries by incorporating supplementary variables and exploring alternative econometric frameworks.