Metabolism and Antiaging Medicine: Sarcopenic Obesity and Antiaging

Sarcopenia is a term that means a decrease in skeletal muscle mass and a decrease in muscle strength with aging. Sarcopenic obesity is a pathological condition in which obesity is combined with sarcopenia, and mechanisms such as insulin resistance, inflammation, and oxidative stress are considered to link obesity and sarcopenia [1]. In obesity, studies have been accumulated focusing on the accumulation of neutral fat in white adipocytes in subcutaneous adipose tissue and visceral adipose tissue. In recent years, in addition to these orthotopic fat accumulations, the elucidation of the pathological conditions of ectopic fat accumulation in fatty muscles, fatty liver, fatty pancreas, and pericardial adipose tissue has been attracting attention. In sarcopenic obesity, where sarcopenia and obesity coexist, fatty muscle is an important element.