The Potyviridae family members consist of single-stranded (positive-sense), monopartite, and bipartite viruses of crop plants with flexuous filamentous particles. This Potyviridae has 244 species that belong to 12 distinct genera, which are separated based on vector specificity, genome organization, and sequence homology (King et al. 2012; Adams et al. 2005a). The 5′ end of the genome is covalently linked with viral genome-linked protein (VPg), and the 3′-terminus is polyadenylated and the genome expresses as a large polyprotein, which is later cleaved into functional proteins, post-translationally by proteases (Riechmann et al. 1992). These genomes include a conserved set of genes that encode for nonstructural proteins involved in RNA replication. The proteins that make up the polyprotein are organized as follows: P1: 1st Protein, HC-Pro: Helper Component, P3: 3rd protein, CI: Cylindrical Inclusion Protein, NIa: Small Nuclear Inclusion Protein, which includes NIb: N-Terminal Viral genome-linked Protein and C-Terminal Protease domain, Large Nuclear Inclusion Protein, and CP: Coat Protein. Small, 6Kd, proteins are located between the CI and NIa and between the P3 and CI protein units. The order of gene and protein sequences is conserved in Potyviridae (Adams et al. 2005a; Inoue-Nagata et al. 2022).