In order to solve the heat dissipation problem of high heat flux components of military electronic equipment, a mechanical pump-driven two-phase flow cooling system was designed in this paper. The thermal performance of the system was tested experimentally at room temperature, high and low temperature and vibration environment. By means of the experimental data and phenomenon analysis, the system had good heat transfer performance under room temperature, high and low temperature, vibration conditions. Under the condition of acceleration environment, the system liquid storage separator won't work normally, the internal liquid would be confused, gathering in a certain part and can't circulate in the system pipeline normally which would result the failure in system. In order to solve this problem, the system can keep working normally under the condition of multi-angle acceleration by increasing the amount of liquid filled in the system.