Modern oncology services strive to deliver comprehensive care to the patients they treat. This includes managing the psychological distress of patients and their family members. A proportion of the cancer patients require formal psychiatric assessment for management of comorbid psychiatric conditions, such as depression, procedural anxiety, anticipatory grief, substance-related disorder, and others with a combination of psychotropic medications and psychological interventions. An integrated psycho-oncology service requires consultant psychiatrists and psychologists working together to make the best possible decision for any individual patient. Psychiatric risk management, including managing suicide risk, is an essential aspect of care to be provided by psycho-oncology services. In this chapter, we discuss the management of common psychiatric disorders in cancer patients across the life span, including children, adolescents, and adults. There are also sections devoted to patients with brain tumors, patients with delirium, management of tobacco cessation, and management of end of life. We sincerely hope that the oncology services of the future will offer genuinely comprehensive cancer care for both body and mind because we believe that there is ‘no health without mental health’.