This paper presents a model for predicting visual comfort of natural lighting office, considering both the horizontal paper work and vertical work with computer screens, based on field experiments and questionnaires. By using the prediction model, an intelligent prediction platform system for visual comfort is built. This paper focuses on the application of visual comfort prediction model in architectural engineering, summarizes and proposes the office space design flow based on natural light visual comfort, and analyzes the feasibility and usability of the design method combined with specific engineering design practice.