Biofouling has always been a crucial issue in the deterioration of masonry construction, which can result in an aesthetic problem, compromise the mechanical quality of historic and archaeological sites and consequently cause a significant economic loss due to the need for façade maintenance and repair. As multiple climate parameters and material properties interact in a complex way and influence algae growth independently, this research aims to have a comprehensive understanding of how both material characteristics and climate parameters influence algae growth (green algae) on brick substrate. Two prediction models were employed and assessed to determine the effect of various conditions on algae growth curve. The results indicate that generally higher wind-driven rain indicates a higher risk of algae development. However, the prevailing impact of wind-driven rain is limited beyond 200 mm annual rain load. Moreover, bricks with more than 90% large pores are the most vulnerable to algae growth, while bricks with uneven pore size distribution are the most resistant.