Phytophthora stem and root rot is a catastrophic plant disease, caused due to Phytophthora sojae. The disease manifests through a range of symptoms, including damping-off, rotting, as well as blighting that ultimately lead to plant death. Epidemiological factors, such as environmental conditions and host susceptibility, greatly influence disease development and spread. Understanding the factors contributing to pathogen dispersal and infection can aid in the formulation of efficient management strategies. Phytophthora stem and root rot management approaches primarily encompass on cultural practices, chemical control, and genetic resistance. Crop rotation, proper drainage, and the use of resistant cultivars are essential components of integrated disease management strategies. Genetic resistance presents a promising avenue for sustainable disease management. The identification and deployment of resistant genes through breeding programs can provide durable protection against Phytophthora stem and root rot. This chapter focuses on the symptomatology, epidemiology, and management strategies employed to mitigate its impact.