In the healthcare domain revolution, emerging technologies provide innovative solutions to enhance patient care and medical research. Each new concept has potential for specific problems, and they also have some challenges. Many technologies are introduced to improve service with security and qualities in healthcare applications like Blockchain, Digital Healthcare Systems, Nano Technology, Augmented Reality, Virtual Reality, and Artificial Intelligence. Blockchain technology yields security and transparency for electronic health records. We elaborate on the benefits and challenges of blockchain in healthcare applications. Powerful technology can be applied to various healthcare domains for the betterment and contribution of innovative solutions to healthcare. Blockchain has multiple features, including distributed ledger, decentralized storage, authentication, security, and immutability, which greatly solve complex healthcare problems. Blockchain plays an essential role in healthcare applications such as preserving and sharing patient data, diagnostic labs, and pharmacy stores to effectively handle narcotic and other prescribed drugs for safe use by clinicians, handling the patient medical records and clinical trial data. Technology also improves the security of patient medical records and the efficient operation of healthcare organizations. One of the recent applications of blockchain in the healthcare system is customized function to personalized medicine in the health information technology by providing shareable private keys by the healthcare providers. In addition, blockchain technology can maintain patients’ health information confidentially, which improves remote access to the individual.