Drug delivery procedure assists in enhancing the efficacy and safety in the administion of therapeutic agents. Certainly, selecting an efficacious drug administration carrier is a significant challenge for researchers. Incorporating polysaccharides and carbon nanomaterials (CNs) in the synthesizing method of nanocomposites can offer a solution to overcome the obstacle of non-biodegradability and minimal biocompatibility properties, and low loading efficiency and controlled and prolonged therapeutic administration affinity of the drug carrier system. The collaborating outcomes arising from the integration of CNs and polysaccharides are underscored, offering a nuanced understanding of their potential as therapeutic delivery vehicles. This chapter serves as a concise overview of the intricate interplay between CNs and polysaccharides, providing valuable insights for researchers and practitioners engaged in advancing nanomedicine for enhanced drug delivery applications.