BRICS Partnership on New Industrial Revolution Innovation Center (hereinafter referred to as “BRICS Innovation Center”) is an important platform for building BRICS Partnership on New Industrial Revolution, deepening practical cooperation among BRICS countries, and expanding the “BRICS+” network. The BRICS Innovation Center is now based in Xiamen of Fujian Province, and a series of activities such as professional training, think tank seminars and industrial innovation competitions have been held. Although the construction of the BRICS Innovation Center has made important progress, it is still confronted with certain obstacles. It is claimed that we should keep in line with the vision of the BRICS Partnership on New Industrial Revolution and BRICS countries’ needs for science, technology and innovation (STI) development and industrial upgrading, focus on the two paths of STI and industrial development, take “multilateralization” as the basic principle, uphold openness, inclusiveness, and win–win cooperation, enhance systematic collaboration, build the future ecosystem of technology industry, establish featured innovation hubs of the Maritime Silk Road, explore the establishment of the BRICS institute of industrial technology, international standardization organizations and the BRICS technology bank, fully mobilize both government and private organizations, and promote high-quality development of the BRICS Innovation Center through diversified investment, mechanism innovation, intellectual property protection and other means.