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Nanopore sequencing has become the primary technology for modern DNA sequencing. Solid nanopores are favored for their cost-effectiveness, stability, and scalability, particularly for portable applications. This paper presents a new design for a portable solid-state nanopore sequencing device based on the Linux platform. It employs a cutting-edge biological sequencing chip with a nanopore channel to capture through-hole data. Electrical signals from the chip are processed to create DNA sequence data files. The Linux-based Raspbian OS serves as the control terminal, facilitating seamless communication between components. Data is then transmitted to a cloud platform via a 5G unit for further analysis. This study integrates software and hardware for instrument validation.

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Scheme Design and Challenges of DNA Sequencing Terminal Equipment Based on Solid-State Nanopore Sequencing

  • 会议论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年

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  • Yuanzhe Zhao,
  • Jie Zhang,
  • Zepeng Sun,
  • Zheqi Cao,
  • Liqun Xu,
  • Jian Li

摘要

Nanopore sequencing has become the primary technology for modern DNA sequencing. Solid nanopores are favored for their cost-effectiveness, stability, and scalability, particularly for portable applications. This paper presents a new design for a portable solid-state nanopore sequencing device based on the Linux platform. It employs a cutting-edge biological sequencing chip with a nanopore channel to capture through-hole data. Electrical signals from the chip are processed to create DNA sequence data files. The Linux-based Raspbian OS serves as the control terminal, facilitating seamless communication between components. Data is then transmitted to a cloud platform via a 5G unit for further analysis. This study integrates software and hardware for instrument validation.