In an urban built environment, numerous issues occur due to air pollution. Wind hazard mitigation, air contamination and transportation near and far from buildings, wind flow direction. The above-highlighted problems and their solution are evident in a sustainable societal structure. The investigation of the above-mentioned issues lies with one of the extremely promising technologies, that is, experimental aerodynamics and wind tunnel technology. Such investigations may bring new insight into understanding the effects of polluted wind flow coming from different directions towards a building and the response of the building in an urban built environment. In this study, the experimental prediction of air pollution dispersion effects on a simplified built environment was studied. The target building which is kept at the Centre of the built environment has been oriented at different wind directions (0°, 22.5°, 45°), and three different wind speeds as 10, 15, and 20 m/s considered for the study of air pollutant dispersion. The experiment was conducted in a subsonic wind tunnel to verify the numerically obtained pressure coefficients (Cp) over a target building. Results revealed that the target buildings are under a severely adverse pressure gradient which might lead to a hazardous situation and higher turbulence is present in the wake zone than near the wall. In the case of 45° orientations, due to the symmetric nature of flow behind the rear surface, the Cp variations are negative because of the pure suction effect of wind. These results show that air pollutants are concentrated near the building wall of the wake zone which leads very uncomfortable situation in the built environment.