Constructed Wetland (CW) is a proven technology to remove organic load efficiently using macrophytes. Microbial fuel cells (MFCs) are bio-electrochemical devices that use microorganisms to break down organic materials to produce power. The electricity generation in MFCs increases as the substrate is microbially degraded more. A hybrid strategy known as CW-MFC was developed as a result of the fact that both CW and MFC function with varying redox potentials. CW-MFC is a newly developed method for producing energy while simultaneously treating wastewater. In this study employing synthetic high-strength domestic wastewater, influent chemical oxygen demand (COD) concentrations ranged from 200 to 800 mg/L, while hydraulic retention time (HRT) ranged from 12 to 24 h. Results showed a COD removal efficiency of 79.8% on average, peaking at 88%. Three techniques were used to analyze the electrochemical behavior: electrochemical impedance spectroscopy, cyclic voltammetry, and linear sweep voltammetry. A polarization analysis found a maximum power density of 62.51 mW/m2 with an internal resistance of 3.74 Ω. This study demonstrates how changes in COD and HRT affect system performance, demonstrating the promise of CW-MFC for effective wastewater treatment and environmentally friendly energy generation.