.This chapter provides a comprehensive overview of the screening, diagnosis, management, and prevention of bipolar disorder in clinical practice. It highlights the limitations of routine screening tools and underscores the importance of thorough history-taking and clinical examination for accurate diagnosis. The diagnostic criteria for both Bipolar I and Bipolar II Disorders are discussed, along with predisposing risk factors and the need to exclude organic causes through appropriate investigations. The chapter also outlines the management of bipolar disorder, including timely psychiatric referral, pharmacological treatment, and post-treatment monitoring of metabolic parameters and physical health. Preventive strategies are explored, such as adherence to maintenance therapy, psychoeducation, and non-pharmacological approaches like Interpersonal and Social Rhythm Therapy (IPSRT). By offering practical guidance, this chapter aims to support early recognition, effective intervention, and sustained long-term care for individuals living with bipolar disorder.