Acne vulgaris is a chronic inflammatory skin condition affecting pilosebaceous units, primarily driven by sebum overproduction, follicular hyperkeratinization, C. acnes colonization, and inflammation. Associated factors include skin trauma, high glycemic diets, insulin resistance, and hormonal influences. Diagnosis involves clinical assessment of lesion type, severity, and distribution. Management includes topical agents (retinoids, benzoyl peroxide, antibiotics), systemic therapies (antibiotics, hormonal agents), and lifestyle modification. Investigations are typically unnecessary unless endocrine disorders are suspected. Treatment failure may stem from poor compliance or resistant strains. Referral is warranted for severe, refractory, or atypical presentations, including acne conglobata and acne fulminans.