This article serves as a comprehensive guide for the screening, diagnosis, management, monitoring, and prevention of Hepatitis B (HBV) and Hepatitis C (HCV) in adults, with a particular focus on the role of primary care. Key topics include risk-based screening criteria, diagnostic approaches using serologic and virologic testing, and staging for HBV. Treatment strategies are outlined for both acute and chronic infections, covering pharmacological and non-pharmacological options. The article also highlights the use of direct-acting antivirals for HCV and antiviral therapies for HBV. Guidance is provided on hepatocellular carcinoma (HCC) screening, patient monitoring, and referral criteria. Preventive measures such as vaccination and post-exposure prophylaxis are emphasized to reduce transmission and overall disease burden.