.Conn’s Syndrome, or primary hyperaldosteronism, is a significant yet frequently underdiagnosed cause of secondary hypertension. This guide offers a comprehensive and practical framework for diagnosis and management, incorporating underrecognized factors such as gender-specific influences, dietary impact, and genetic predispositions. It provides detailed guidance on advanced diagnostic techniques and localization strategies to ensure accurate detection and differentiation of disease subtypes. Treatment approaches—both surgical and medical—are individualized, with an emphasis on comorbidity management and long-term follow-up. By addressing limitations in existing resources, this guide empowers clinicians to deliver precision care and improve patient outcomes.