Sexual dysfunction encompasses a range of issues affecting desire, arousal, orgasm, and pain during sexual activity in both men and women. Screening includes open-ended questions and validated tools like MSHQ or FSFI. Diagnosis involves thorough history-taking, physical examination, and targeted investigations. Causes may be psychological, physiological, hormonal, or medication-related. Management includes counseling, sex education, addressing comorbidities, and pharmacotherapy such as PDE5 inhibitors or hormonal therapy. Referral is advised for longstanding or complex cases, multiple dysfunctions, suspected abuse, psychological disorders, or treatment resistance. A patient-centered, multidisciplinary approach is essential for effective evaluation and treatment of sexual dysfunctions.