This chapter synthesizes the findings from the 12 case studies presented in this volume. It is designed to answer the following questions: (1) How can we conceptualize the connections between business and biodiversity in the context of managing socio-ecological production landscapes and seascapes (SEPLS)?; (2) How can we measure, evaluate, and monitor impacts and dependency of businesses on biodiversity and nature’s contributions to people through managing SEPLS?; and (3) How can we address challenges and seize opportunities in SEPLS to effectively manage business impacts on biodiversity, ecosystems, and human well-being? In addition to addressing these questions based on the synthesis of the case study findings, the chapter provides recommendations for policymakers and other stakeholders to ensure that the processes and outcomes are ecologically and socially sound and equitable in promoting more sustainable businesses. These recommendations are examples of ethical, equitable, and actionable ways of ensuring that businesses are sustainable while conserving biodiversity. In that way, businesses can contribute to achieving multiple sustainable development goals (SDGs) simultaneously, including not merely those specific for life below water and on land but also those related to poverty reduction, food security, good health and well-being, gender equality, quality education, capacity development, employment, climate action, responsible consumption and production, and partnerships and institutional development.