The fashion industry is going through a massive transformation due to recent advancements such as Industry 4.0 mainly propelled by technological interventions like artificial intelligence (AI) and robotics. This chapter explores the application of AI and robotics in the fashion industry focusing on its manufacturing and supply chain operations. It attempts to shed light on contemporary technologies, deliberates their potential benefits, figures out challenges, presents successful case studies, and proposes future research avenues. Fashion businesses may increase customer satisfaction and gain a competitive edge by leveraging AI and robotics to improve productivity, performance, and agility throughout the production process and supply chain. Further, it helps to drive sustainability in the fashion businesses by unlocking new horizons in the fashion industry.