The population explosion and climate change in the growing world have become a serious concern with respect to the sustainability and production of crop plants. In this modern era, it has become essential to achieve a balanced production and harvesting of crops by minimizing the impact of pathogens and climate change. The Green Revolution has become successful in achieving the improved production of crops. However, the rising incidence of susceptibility of crop plants to diseases and the high demand for crop yield makes the scientific world think of newer and improved techniques to mitigate the problems associated with the production of high-yield disease-resistant crops. According to a United Nations assessment, to feed the world's population and end hunger by the year 2030, food output must be improved and sustained. The present-day available molecular and genetic methods of crop improvement are widely used in the production of better crop yield in terms of quality and quantity. However, limitations in time and resource utilization with more target-specific genome engineering require the search for advanced techniques of target-specific genome editing. Plant genome editing now makes considerable use of the Clustered regularly interspaced short palindromic repeats-associated protein (CRISPR-Cas) technology. It is one of the most widely accepted and improved tools in the production of disease-free and high-yielding food crop varieties. The use of CRISPR-cas tools will boost the agricultural production of improved crop cultivars compared with conventional breeding.