Ticks transmit disease agents to humans and animals, causing health problems and economic losses. Tick control is currently based on synthetic acaricides; however, effective control and prevention of tick infestation remain distant goals. In recent decades, a progressive decrease in the efficiency of acaricides due to drug resistance has been observed. Tick resistance can be caused by two main mechanisms: (1) toxicodynamic resistance, where mutations in tick genes make them less susceptible to acaricides, involving changes in the target sites where acaricides bind or alterations in how these chemicals work within the tick; and (2) toxicokinetic resistance, where ticks develop ways to detoxify or eliminate acaricides more efficiently, involving increased activity of enzymes that break down acaricides or changes in how acaricides are transported within the tick’s body. The widespread use of acaricides selects for resistant tick populations, which emphasizes the need for judicious use of these chemicals and the development of alternative tick control methods. Understanding the tick resistance mechanisms is crucial to overcoming this challenge and protecting human and animal health.