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This chapter focuses on topics related to synthesizing PEGylated nanocarriers and their characterization. The types of poly(ethylene glycol) (PEG) derivatives and conformation in addition to PEGylation techniques are detailed. Moreover, the methods employed for synthesizing PEGylated nanocarriers are categorized and discussed in detail. The methods explained are classified into self-assembly from PEG-containing molecules by either nanoprecipitation or emulsification and surface modification of nanocarriers with PEG chain covalently and noncovalently. Indirect assessments of surface PEGylation efficiency using particle size, surface hydrophilicity, zeta potential, etc. are emphasized, in addition to other methods used for direct assessments, including colorimetric methods, chromatographic quantification methods, UV and fluorescence spectroscopy, and more. Finally, alternative polymers to PEG are briefly illustrated, as well as the challenges of nanocarriers PEGylation.

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Methods and Protocols for the Synthesis of PEGylated Pharmaceutical Nanocarriers

  • 章节

  • 发表日期：

    2025年

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  • Ala’ Adnan Ali,
  • Rakesh Kumar Tekade,
  • Randa S. H. Mansour

摘要

This chapter focuses on topics related to synthesizing PEGylated nanocarriers and their characterization. The types of poly(ethylene glycol) (PEG) derivatives and conformation in addition to PEGylation techniques are detailed. Moreover, the methods employed for synthesizing PEGylated nanocarriers are categorized and discussed in detail. The methods explained are classified into self-assembly from PEG-containing molecules by either nanoprecipitation or emulsification and surface modification of nanocarriers with PEG chain covalently and noncovalently. Indirect assessments of surface PEGylation efficiency using particle size, surface hydrophilicity, zeta potential, etc. are emphasized, in addition to other methods used for direct assessments, including colorimetric methods, chromatographic quantification methods, UV and fluorescence spectroscopy, and more. Finally, alternative polymers to PEG are briefly illustrated, as well as the challenges of nanocarriers PEGylation.