The Cullin-RING Ligase Family in Immune Regulation

The Cullin-RING ligase (CRL) E3 family is the largest ubiquitin ligase family and consists of a catalytic subunit, a scaffold protein, an adaptor, and a substrate receptor. Each component is different in the different members of the CRL family. CRLs affect the ubiquitination and stability of multiple substrates and regulate many biological processes. In immune regulation, components of CRLs also play critical roles in different types of immune cells and under different physical or pathological conditions. In this review, we summarized the recent advances in research about the functions of CRLs in immune regulation. Different components of the CRL family are associated with the regulation of different immunological processes.