The dynamic relationships that exist between microorganisms and minerals in various levels of environmental settings are in term referred to as microbe–mineral interactions. These interactions affect nutrient availability, soil structure, and the fate of contaminants. They include processes like mineral weathering, dissolution, and precipitation mediated by all types of microorganisms. As bioindicators, emphasize the microbial communities and their relationship due to pollution, which provide information about the extent and impact of contamination on the environment. The complex interactions between microbes and minerals affect biogeochemical cycles, ecosystem structure and function, and environmental management in profound patterns. By influencing mineral transformations that impact nutrient cycling, soil health, and involved pollutants through various mechanisms that contribute to the immobilization, degradation, or detoxification of pollutants, microbe–mineral interactions play a crucial role in environmental pollution and management. Providing insightful information for ecosystem restoration and sustainable remediation techniques. In this chapter focused on various forms of microbe–mineral interactions and their effectiveness in managing environmental pollution with reference to amelioration and restructuring the soil health.