Antimicrobial Silicone Catheter by In-situ grafting of Nanosilver Nanohydrogel

Polydimethyl siloxane (PDMS) catheter was functionalized by γ-irradiation process to develop infection-resistant antimicrobial material. A two-step approach was used to develop antimicrobial catheter. The catheter was immobilized with the nanosilver nanogel (nSnG) using the irradiation process. The nSnG was prepared by γ –irradiation of water-in-oil nanoemulsion. The catheter was irradiated in the presence of the nSnG so that in-situ grafting of nSnG takes pace in catheter. The functionalized catheter showed excellent antimicrobial nature in terms of biocidal effect against E. Coli and S. aureus.