Substitute to cement as a binding medium are becoming more popular due to rising demand for concrete and the fact that cement production responsible for large amount of carbon emissions. Previous research has demonstrated that mineral admixtures (MAs) such as flyash, micro silica, GGBS, metakaolin, nano materials, and so on may be used to partially replace cement. Finer mineral admixtures densifies the pore structure, resulting in improved mechanical and durability characteristics. This study examines acid resistance quaternary blended concrete using mineral admixtures such as Metakaolin (MK), Flyash (FA), and Nano silica (NS). MK at 10%, FA at 30%, and NS at 3%. Quaternary Blended Concrete (QBC) and Control Concrete (CC) specimens were evaluated for acid resistance with 5% HCl & H2SO4. The observations made on different aspects of Specimens. According to findings, QBC compounds are having more against acids. This increase might be due to the inclusion of the mineral admixtures, which resulted in a denser and more refined microstructure. The increase might possibly be related to the compact interfacial zone of transition. Due to increased performance, SCMs which are waste/bi-products of industries, can be employed in high-strength/high performance concrete, reducing the cement content and reducing carbon emissions. Since flyash which is responsible for later age, Metakaolin and Nano silica was added as they are responsible for the early strength and also improves overall strength. Metakaolin 15% or more and Nano silica more than 3% reduces the strength as observed in previous researches.