Base isolated buildings perform better than non-isolated building when subjected earthquake ground motion. Earthquakes are unpredictable and it can hit the building from any direction. Thus, this study examines how incident angle of ground motion affects the isolated building. For this an isolated and a “non-isolated building” was modelled by using SAP2000. The ground was applied at seismic incidence angle 0°, 30°, 60°, 90°, 120°, 150° and 180° with the principal X axis of the buildings. The responses in terms of base shear and storey displacements have been compared for both the models for the seven load cases using time history analysis (THA) In this study, it was discovered that seismic energy dissipation was maximum for along the shorter span of the isolated building with seismic ground motion applied at 90° with the principal X axis of the building plan. The storey displacements and base shear in X direction were found to be maximum at incidence angle 0° and 180°, while these were found maximum in Y direction at incidence angle 90°.