In the screw compressor, the screw rotors are the vital component. The machining accuracy for rotors is mainly affected to the screw compressor performance. However, the axis errors of the grinding wheel are often existed in the manufacturing process. To enhance the accuracy for rotor manufacturing, the effecting evaluation of axis errors of the grinding wheel to the tooth profile of the screw rotor is necessary. Therefore, a numerical simulation method is proposed to estimate the grinding wheel axis errors to the rotor profile of screw compressor. It is built to a software by using C# programming language. The validity and advantages of the proposed method are demonstrated via numerical examples.