The paper presents the concept, design, and verification of a cyber-physical facility intended for testing of the thermal management system (TMS) designed for an electric vehicle with individually driven wheels. The basic functionality of the test system is implemented using Component-in-the-Loop (CiL) technology with the TMS embodied as a physical entity that interacts with virtual models of the electric drive components by means of devices emulating thermal and hydraulic behaviors of those components. The operating environment of the TMS is physically imitated by a model-driven air fans and a climatic chamber. Expanding the system’s functionality is achieved by means of X-in-the-Loop technology that enables remote test facilities, housing different components of the vehicle and its powertrain, to connect and interact in real time through computer networks. Using that technique, the CiL system is connected to a remote laboratory that houses a setup intended to test the individual-wheel-drive controller in Software-in-the-Loop (SiL) mode employing virtual models of the electric vehicle, its powertrain, and the driving environment. Interaction between the CiL and the SiL facilities allows testing the TMS in operating modes occurring when the vehicle runs through a driving cycle in specified ambient conditions. The test results presented in the paper prove the developed X-in-the-Loop architecture to be operational and adequately replicating behavior of the studied system.