Nylon 66 polymers and their composite materials are widely utilized across various engineering sectors, including the aerospace and automobile industries, primarily due to their exceptional lubrication capabilities. Therefore, it is important to study the stress flow in Nylon 66 under different strain rates. In this study, the behaviors of Nylon 66 under low to high strain rates have been presented. The sensitivity of nylon 66 for different strain rates are measured by the compression-testing machine (CTM) and Split-Hopkinson Pressure Bar (SHPB). A 3-dimensional Finite element (FE) model has been made in Ls-dyna. Calibration of the numerical result has been done with the experimental result by using the Johnson–Cook (JC) material model and plastic kinematic material model for rods of SHPB and Nylon-66, respectively. The calibrated model is used to study the effect of strain rate and shape of Nylon-66, and simulated results are presented in this paper. The quasi-static strength of Nylon-66 measures 60 MPa, under a strain rate ranging from 0.0006 to 0.001 s−1. In dynamic tests, the strain rate varies considerably, ranging from 400 to 3380 s−1. Accomplished by adjusting the striker velocity from 2 to 16 m/s. Notably, for circular sections, the dynamic strength of Nylon-66 exhibits a remarkable increase, rising from 82.42 MPa at a strain rate of 400 s−1 to 316.59 MPa at a strain rate of 3380 s−1. Similarly, in equivalent square sections, the strength varies from 70.92 to 301.45 MPa.