The progressive collapse of multi-story buildings has attracted the attention of structural engineers in the recent past. Progressive collapse is initiated by the sudden loss of vertical load carrying key elements. It causes a series of failures that lead to the partial or total collapse of a structure. In the present study, different factors that influence the progressive collapse resistance capacity of a structure are investigated. The factors include the nature of the event causing the loss of a key element, structure properties such as span length, member sizes (beam and column), and location of column removal. A nonlinear time history analysis of the building is performed for the progressive collapse using Etabs 2020 software. The response quantities include the number of plastic hinges formed, vertical displacement, and rotation of joints. The findings reveal that increasing beam depth and reducing grid span enhance structural robustness, effectively resisting bending moment and shear force.