Unreinforced masonry (URM) walls carry axial loads and do have openings. Variation in the axial load and location of opening are not uncommon in masonry buildings. To investigate the response of URM walls carrying varying axial load and location of opening, wall with dimension 5000 mm × 3010 mm × 230 mm that carries axial load of 51, 30, and 9 kN/m corresponding to wall of 1st, 2nd, and 3rd storey, respectively, having rectangular opening at (1) edge, (2) ¼ length, and (3) ½ length of the wall, has been considered for the analysis using the Abaqus tool under the 10kg-TNT at 1m distance of explosion. The walls are modelled with CDP model following microscopic technique. Damage, displacement and stress response are examined and the best/worst location of the opening is highlighted. The wall with opening at extremity carrying high axial load has been found giving the worst performance.