Nutrigenomics and Stroke

Stroke, a significant public health concern causing considerable morbidity and mortality worldwide, stands as a primary instigator of functional disability. Its multifaceted and enigmatic nature emerges from an intricate interplay of specific risk factors, including genetic elements. Delving into the intricate landscape of stroke causes, this review illuminates both monogenic and polygenic origins, meticulously elucidating the nexus between genes and diet. Nutrigenomics, an emerging field studying how nutrients interact with genes, holds promise in stroke prevention and management. This review aims to synthesize the current state of knowledge on nutrigenomics in stroke, encompassing the genetic foundations, nutrient impact on risk and outcomes, and the potential for personalized prevention and treatment. Within this exploration, a keen focus is directed towards unravelling the dynamics of CADASIL and MELAS. Investigating the latest research on nutrient-gene interactions in stroke, including dietary patterns and individual nutrients, this paper underscores the importance of a multidisciplinary approach to stroke care, involving healthcare professionals, patients, and caregivers. The findings suggest that nutrigenomics could revolutionize stroke management, enhancing the quality of life for survivors and families. However, a call for further research echoes throughout, urging advancements in nutrigenomics to translate findings into clinical practice. Ultimately, this review serves as a valuable resource for healthcare professionals, researchers, and policymakers, contributing significantly to the global mission of alleviating the societal burden imposed by stroke. CADASIL: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy MELAS: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes