Health Consequences of Circadian Disruption in Humans and Animal Models During Aging

The circadian system, which controls a variety of rhythms in our bodies, is under a lot of stress in modern times. With the demand for products and services expanding throughout the day, rapid industrialisation and globalisation of the economy, and nontraditional work schedules are becoming increasingly prevalent. Employees who work shifts that involve the night must stay awake when their biological clocks signal inactivity. A growing body of research suggests that shift work raises the risk of several major physiological and psychological conditions, including cardiovascular disease, metabolic syndrome, obesity, immunological dysfunction, cancer, and problems during pregnancy. Due to survivorship bias and self-selection, epidemiological studies may understate shift employment’s negative effects on health.