Mechanoimmunological Coupling Mechanism in DC Sensing Mechanical Stimulation in the Microenvironment

Dendritic cell’s (DC) function is crucial to the outcome of the immune response and affects the process of disease. In addition to the biochemical factors in the microenvironment, the immune functions of DCs are also regulated by mechanical factors. From a mechanical viewpoint, the mechanosensitivity and conductance of immune cells are intimately linked to their immune phenotype. Herein, a model for the implantation of bone plates was created to assess the in vivo recruitment of DCs and fibrin matrix deposition. A 2D and 3D fibrin matrix model was used to further examine the reactions of DCs to mechanical stimulation in vitro. Furthermore, we reviewed the latest accomplishments by encompassing the advances in the mechanical sensing and transduction of DCs, as well as the relationship between mechanophenotypes and immunophenotypes. This finding has significant implications for future advancements in mechanoimmunology.