Cement, aggregate, mineral admixture, concrete admixture, and mixing water were used as the main raw materials to prepare manufactured sand concrete. By adjusting the proportioning parameters of manufactured sand concrete, such as sand ratio and water-cement ratio, the influence of proportioning parameters on the durability of manufactured sand concrete was studied. Experimental results show that when the sand ratio is between 0.38 and 0.44, the mechanism of sand best workability and durability of the concrete strength, the best value for the mechanism of sand concrete, sand ratio range within the scope of the young stage of mechanism sand concrete stress is almost not affected by sand ratio increase, age stage mechanism of sand concrete stress along with the increase in sand ratio decreased significantly; The stress of natural medium sand concrete and manufactured sand concrete increases with the increase in the water-cement ratio, and the compressive strength of manufactured sand concrete is slightly higher than that of ordinary natural sand concrete. When the stone powder content is 10.5%, its filling performance is better, and the frost resistance of mechanized sand concrete can be improved by adjusting the stone powder content. When the powder volume is 158 dm3, the manufactured sand concrete has good workability and the highest durability. The increase in the water-binder ratio will lead to the aggravation of carbonization depth, serious carbonization phenomenon, and reduced durability of machined sand concrete.