With the technological development of resilient city and intelligent transportation, since the terminal equipment of real-time monitoring and safety monitoring system for lifeline projects is usually set up in highway monitoring halls, more and more highway monitoring centers in China's seismic high intensity areas assume the important function of emergency command centers after earthquakes. In order to ensure that the monitoring and surveillance equipment can operate normally during an earthquake, this paper puts forward a proposal to adopt seismic isolation technology for the monitoring center, and gives the performance objectives and quantitative indexes based on performance-based seismic design. Through the finite element numerical simulation and nonlinear time course analysis of engineering examples, the results show that: the inter-story shear force, inter-story displacement, floor acceleration and other dynamic response indexes are greatly reduced compared with the pre-seismic isolation, which can realize the setup goal of monitoring and controlling the building for uninterrupted use in earthquakes and assuming the function of emergency rescue and command, and effectively verifies the reasonableness of the performance goals set in this paper. At the same time, from the perspective of the whole life cycle of building and equipment maintenance, the use of seismic isolation design can also save costs. The research content of this paper provides a theoretical basis for the feasibility of promoting seismic isolation structures in the field of highway monitoring buildings.