This article describes methods that were used in 10th grade to solve problems associated with the fact that students receive more theoretical knowledge and do not know how to apply it in practice. In implementation, STEM education in the learning and teaching process helps develop students’ research skills, such as making scientific hypotheses, identifying and solving problems. We chose this particular parallel, since students aged 16–17 have sufficient knowledge to analyze and evaluate information in order to put forward theories and implement them in practice. This is also relevant for the students themselves, because they already need to decide on their future profession, and practical tasks aimed at solving various life situations contribute to the development of the necessary skills. To develop these skills in students, we used STEM teaching methods, such as posing a problematic question, putting forward hypotheses, conducting experiments, conducting our own research, analyzing and evaluating the data obtained, reflection and working to improve results. The implementation of these methods in our pedagogical practice showed the effectiveness of their application because it could be noticed that the students had more pronounced skills described above, which were assessed by design work, some of which even took places in scientific project competitions at various levels. During the lessons, students began to ask high-order questions, put forward hypotheses, determine the most correct ones, and justify their choice. Students also began to independently identify problems and propose solutions, arguing why this particular solution is the most optimal. Along with this, future graduates are required to have knowledge of functional and information literacy, which the use of STEM teaching methods helps develop. Thus, we came to the conclusion that the use of STEM teaching methods in the classroom helps not only to integrate subject knowledge in mathematics, physics, biology, chemistry and computer science, but also develops practical and research skills that are fundamental to being competitive, capable and successful in the professional field. Now students have learned to look at a problem from the perspective of all subjects, which give them the opportunity to choose the most rational way among all possible alternatives.