Buildings with deficiencies are severely damaged during seismic events. Buildings with multiple irregularities are more vulnerable to earthquakes. Many such buildings exist and are being constructed both in urban as well as rural areas of developing countries. The awareness of the behaviour of such buildings with multiple irregularities during seismic events is less. The earthquake events have demonstrated the failure patterns of the deficient reinforced concrete buildings. Even then the awareness of the behaviour of such buildings with multiple irregularities during seismic events is less. Hence, an attempt is made in this study to analyse the buildings with multiple irregularities using the structural analysis software SAP2000. The irregularities considered in this study are soft-storey and, plan irregularity wherein the center of mass does not coincide with the center of stiffness named as torsional irregularity. Various response parameters such as relative displacement, acceleration amplification, base shear, and torsional responses are evaluated. Failure modes of the buildings with irregularities are studied and the code provisions on seismic performance of deficient reinforced concrete buildings are reviewed.