Although the confined masonry (CM) construction has shown good seismic performance but, in some cases, it has also experienced significant damage. The majority of damages were reported in the walls with openings, due to the absence of appropriate confining elements around the openings. Thus, the in-plane lateral response of perforated CM walls without and with confining elements have been evaluated using experimental investigation. Initially, two perforated CM walls without confinement around the openings were tested under quasi-static in-plane cyclic loading. Thereafter, CM walls having confinement around the openings were constructed and tested under similar loading cycle. The experimental study showed that the presence of tie-members around the openings was highly efficient in enhancing various performance parameters of the CM walls such as its in-plane capacity, energy dissipation, stiffness degradation and strength degradation. It was observed that the CM wall with confinement around window opening was able to achieve the strength more than twice of its respective wall. Further, the cracks were uniformly distributed in the CM walls with confined opening and no major failure was observed in the walls even at higher drift levels.