Healthcare industries have boomed in the last couple of years. Due to that, cyber security is the main key concern for medical systems. The objective of this systematic review is to identify the common cyber hacker attacks and to identify the best possible solution. In this Chapter, we have used the PRISMA model to select multiple articles from the web of science, EBSCO, and Google Scholar between 2010 and 2021. In this study, Types of Healthcare Data Types, Common Hacker attacks, and types of Security parameters concerning the healthcare sector has discussed to understand healthcare security issues. Also highlighted some Healthcare Cyber Security challenges and Healthcare Cyber Security Tools. The main role of Blockchain-Based security in Healthcare and Cyber Security in Medical Devices has also discussed in this study. Additionally, we have provided a comparative analysis of various authors by highlighting their work based on multiple healthcare components and challenges existing systems face. We have also provided the five investigations study along with their solutions. In the future, developing a cohesive plan in healthcare security is recommended to prevent severe cyber-attacks.