In Southeast Asia, Japanese encephalitis is a commonly prevalent vector-borne viral encephalitis with high mortality and morbidity. Half of the survivors of Japanese encephalitis present with some sort of neuropsychiatric sequel. Neuropsychiatric sequel is commonly milder in intensity; however, 10–15% of people have moderate to severe neuropsychiatric sequel. Pediatric patients are more likely than adults to acquire neuropsychiatric sequelae. Seizures, sensory-motor abnormalities, cognition deficits, mood disorders (depression), anxiety, psychosis, and sleep difficulties are common neuropsychiatric sequels in Japanese encephalitis survivors. The neuropsychiatric sequel among the survivors of Japanese encephalitis needs adequate treatment or rehabilitation, which will improve the quality of life of these survivors.