Novel Core–Shell Design for Polymeric Micelles

Polymer micelles, which are core–shell nanoparticles, are a basic technology that enhances the effectiveness of anticancer drugs, and have made steady progress, such as proceeding to clinical trials. On the other hand, in recent years, with the increase in disease needs, pharmaceutical seeds such as nucleic acids, proteins, and viruses have become diversified, and nano-drug delivery system (nano-DDS) technology for improving efficacy and safety is indispensable for their practical application. In such background, it is assumed that even in the development of polymer micelles, technological development based on new material design is necessary in order to realize innovative pharmaceuticals. In such a context, this chapter describes the new shell design to solve PEG dilemma issue and the new core design to incorporate proteins and bioactive nanoparticles toward realization of smart polymeric micelles.