Functional Nanoprobes for Surface-Enhanced Raman Spectroscopic Detection of Cancer Biomarkers
摘要
The development of highly sensitive and selective techniques for the detection of cancer biomarkers and other biomolecules is essential for enabling point-of-care early screening and diagnostics of cancers. Plasmonic metal nanoparticles such as gold and silver produce a localized electromagnetic field enhancement for ultrasensitive and selective surface-enhanced Raman spectroscopic (SERS) detection. This technique depends strongly on the size, shape, and composition of the nanoparticles, but also their surface, interfacial, and interparticle spatial and functional properties. This chapter describes some recent progress in developing plasmonic gold or silver nanoparticles and the plasmonic-magnetic composite nanoparticles with controlled size and composition as SERS-active nanoprobes. Examples in SERS detection of cancer biomarkers will be highlighted. Insights into harnessing the interparticle spatial properties and interactions based on theoretical modeling will also be discussed.