The Role of Coagulopathy in the Pathogenesis and Prevention of Corticosteroid-Induced Osteonecrosis
摘要
In nontraumatic osteonecrosis (ON) of the femoral head, several abnormalities in the coagulation-fibrinolysis system have been reported, including increase of plasminogen activator inhibitor-1 level [1], the presence of antiphospholipid antibodies [2], familial heterozygous protein S deficiency [3], and antithrombin III deficiency [4]. These abnormalities are thought to induce hypercoagulability in the blood vessels.