Development of Simple and Sensitive CPE-Based Electrochemical Sensor for Detection of Quercetin

Quercetin (QUR), a widely distributed plant-based flavonoid, has many important medicinal properties, which is why it is extensively used in various types of food supplements, beverages, and drugs, of course within an acceptable daily consumption limit. As a result, there is a need for the development of rapid and inexpensive mechanism that can detect the presence of Quercetin. In this paper, a simple, highly cost-effective, and sensitive carbon paste electrode (CPE)-based electrochemical sensor is developed for detecting the active biomolecule, Quercetin. The developed sensor has been used to investigate the electrochemical nature of QUR by performing electroanalysis using an efficient three-electrode system approach. The voltammetric response exhibits the satisfactory detection of QUR of various concentrations in the range of 5–200 µM with 0.1 M PBS 5. The LOD was evaluated to be 0.206 µM. The appropriate buffer and pH of the medium was selected using optimization study. The effect of scan rate variation was investigated in the range of 0.01–0.25 V s−1. The statistical analysis using PCA was also performed on the voltammogram data obtained from concentration variation study considering five different QUR concentrations with SI value of 10.1695 for effective data clustering.